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Over the counter metformin substitute to prevent weight gain after gastric bypass. The clinical use of metformin is restricted to patients with type 2 diabetes, and its use at therapeutic doses to reduce diabetes-related comorbidity would provide significant added benefits over other therapeutic options for this patient population. We conducted a meta-analysis that examined the relative efficacy of two metformin product combinations: atorvastatin vs. metformin. RESULTS: Of the 18 studies (841 patients) included in the meta-analysis, metformin combination was associated with a reduced incidence of serious cardiovascular events (risk ratio [RR] = 0.70, 95% confidence interval [CI], 0.59-0.84; I(2) = 62%) and major bleeding events (RR = 0.69, 95% CI, 0.55-0.89; I(2) = 82%; 18 studies) (P <.0001), compared with the combination of atorvastatin and metformin (RR = 0.65, 95% CI, 0.46-0.91; I(2) = 79%; 10 studies). CONCLUSIONS: In patients at risk for non-insulin-dependent diabetes mellitus with an established cardiovascular or metabolic disorder, the combination of atorvastatin and metformin is associated with a significantly reduced rate of major cardiovascular events and bleeding compared with metformin alone.
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